Today I started writing up user documentation for the project I'm wrapping up.  It's the first time I've used 
reStructuredText, and I must say that I'm liking it.  As far as structured text markup languages go, it's pretty comprehensive and not *too* obtrusive.  It's definitely good enough for most technical documentation needs, and is in fact a 
PEP Formatting Standard (see also 
PEP 12 Source).  Other items of interest, particularly to Python programmers, are:
I include the source links to show the relative cleanliness of the markup, which is the point of all 
Structured Text formats.  
sigh  I thought I'd have more to say, but I'm really too tired.  So - quick wrap up: I was pretty productive with this stuff right off the bat.  Nice.
For "Zope", there is a 
proposal to integrate reStructuredText into Zope, hopefully for 2.7.